Methods to Mitigate Injury from Radiation Exposure

US 10,639,296, assigned to Henry Ford Health System, covers a method of mitigating radiation induced injury to a mammal that has been exposed to radiation by administering a pharmaceutically effective amount of a composition comprising at least one CXCR4 antagonist to the mammal, and is available for sale through IPApproach.

US Patents

1 granted

Foreign Counterparts

2

Assignee

Henry Ford Health System

Availability

For Sale

Patents Included

• US 10,639,296↗

• EP 2493295 A1
• WO 2011053700 A1

Technology Highlights

• The invention allows reduction in injury to a particular tissue or to other organs /tissues as well.
• The invention reduces late tissue injury, including skin, in the time after a radiation exposure.
• The invention offers the best effective treatment when started after the radiation exposure, particularly when started one week after.
• The invention CXCR4 antagonists (AMD-3100) mitigates radiation injury following localized skin irradiation, and mitigates radiation injury to other organs using this or a similar approach.
• The invention has the potential to benefit for the three distinct groups of individuals: victims in the unfortunate event of a radiological attack or nuclear disaster; clean up workers following these events; and patients undergoing radiation therapy.
• The invention can reduce the lethality of the mammals after their subjection to radiation.

Overview

The technology disclosed provides the following advantages:

Listing updated August 21, 2026

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